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Preview Modelling of the blood-brain barrier transport of morphine-3 ... pdf file

The half-life of M3G was 81+25 min in brain ECF vs 22+2 min in blood (P50.0001 ). Blood ... British Journal of Pharmacology (2000) 131, 1784 ± 1792. Keywords: ...... be likened to a `gate keeper' effect, hindering M3G transport into the brain.

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